Mechanics of Microtubule-Based Membrane Extension
نویسندگان
چکیده
We observe quasistatic deformation of lipid vesicles from within, due to the polymerization of confined microtubules. A pair of long, narrow membrane sleeves appears, sheathing the microtubule ends as they grow. Spontaneous buckling reveals that the force generated can be greater than 2 pN. The evolution of shape and magnitude of force are consistent with a simple theory for the membrane free energy. We consider a model of the force generating mechanism in which thermal fluctuations of the membrane are “rectified” by the binding of tubulin dimers to the microtubule end. [S0031-9007(97)04450-5]
منابع مشابه
Free Vibration Analysis of Microtubules as Orthotropic Elastic Shells Using Stress and Strain Gradient Elasticity Theory
In this paper, vibration of the protein microtubule, one of the most important intracellular elements serving as one of the common components among nanotechnology, biotechnology and mechanics, is investigated using stress and strain gradient elasticity theory and orthotropic elastic shells model. Microtubules in the cell are influenced by internal and external stimulation and play a part in con...
متن کاملDynamic Simulation and Mechanical Properties of Microtubules
This work is conducted to obtain mechanical properties of microtubule. For this aim, interaction energy in alpha-beta, beta-alpha, alpha-alpha, and beta-beta dimers was calculated using the molecular dynamic simulation. Force-distance diagrams for these dimers were obtained using the relation between potential energy and force. Afterwards, instead of each tubulin, one sphere with 55 KDa weight ...
متن کاملTime integration of rectangular membrane free vibration using spline-based differential quadrature
In this paper, numerical spline-based differential quadrature is presented for solving the boundary and initial value problems, and its application is used to solve the fixed rectangular membrane vibration equation. For the time integration of the problem, the Runge–Kutta and spline-based differential quadrature methods have been applied. The Runge–Kutta method was unstable for solving the prob...
متن کاملSmart Flat Membrane Sheet Vibration-Based Energy Harvesters
The dynamic responses of membrane are completely dependent on Pre-tensioned forces which are applied over a boundary of arbitrary curvilinear shape. In most practical cases, the dynamic responses of membrane structures are undesirable. Whilst they can be designed as vibration-based energy harvesters. In this paper a smart flat membrane sheet (SFMS) model for vibration-based energy harvester is ...
متن کاملFormation of membrane networks in vitro by kinesin-driven microtubule movement
Certain intracellular organelles such as the endoplasmic reticulum (Terasaki, M., L. B. Chen, and K. Fujiwara. 1986. J. Cell Biol. 103:1557-1568) and lysosomes (Swanson, J., A. Bushnell, and S. C. Silverstein. Proc. Natl. Acad. Sci. USA. 84:1921-1925) form tubular networks that are closely aligned with microtubules. Here we describe the formation of polygonal networks composed of interconnected...
متن کامل